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Comment by Dr. Krishna Kumari Challa on May 22, 2021 at 6:39am

Authors can now submit to eLife and medRxiv at the same time

With the support of eJournalPress and medRxiv, authors can now submit their preprint to medRxiv and have it transferred to eLife for consideration at the same time. Alternatively, they can choose to send their manuscript from the eLife submission system directly to medRxiv. eLife is the first journal to facilitate this kind of bidirectional integration with medRxiv into its process, as we lead the way into transforming medical publishing. https://elifesciences.org/inside-elife/037ef19d/elife-latest-author...

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:42pm

Scientists find new way of predicting COVID-19 vaccine efficacy

The early immune response in a person who has been vaccinated for COVID-19 can predict the level of protection they will have to the virus over time, according to analysis from Australian mathematicians, clinicians, and scientists, and published in Nature Medicine. The researchers have identified an immune correlate of vaccine protection. This has the potential to dramatically cut development times for new vaccines, by measuring neutralising antibody levels as a proxy for immune protection from COVID-19. Professor Jamie Triccas from the University of Sydney School of Medical Sciences, and Dr Timothy Schlub from the School of Public Health, Faculty of Medicine and Health were co-authors on the study. Neutralising antibodies are tiny Y-shaped proteins produced by our body in response to infection or vaccination. They bind to the virus, reducing its ability to infect,” says Dr Deborah Cromer from the Kirby Institute.

“While we have known for some time that neutralising antibodies are likely to be a critical part of our immune response to COVID-19, we haven’t known how much antibody you need for immunity. Our work is the strongest evidence to date to show that specific antibody levels translate to high levels of protection from disease.”

The researchers analysed data from seven COVID-19 vaccines to examine the how the response measured soon after vaccination correlated with protection. They then used statistical analysis to define the specific relationship between immune response and protection. Their analysis was remarkably accurate and was able to predict the efficacy of a new vaccine.

Dr Cromer said that this finding has the potential to change the way we conduct COVID-19 vaccine trials in the future.

“Antibody immune levels are much easier to measure than directly measuring vaccine efficacy over time. So, by measuring antibody levels across the range of new vaccine candidates during early phases of clinical trials, we can better determine whether a vaccine should be used to prevent COVID-19.”

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:39pm

Rare blood clots more likely after COVID-19 infection than from vac...

The rare blood clot disorder reported by some Johnson & Johnson coronavirus vaccine recipients is also a risk of COVID-19 infection, according to a new report by the American Heart Association/American Stroke Association Stroke Council Leadership. Dr. Karen L. Furie, chair of the Department of Neurology at Brown's Warren Alpert Medical School, served as lead author of the report, which synthesized existing data from more than 81 million patients and found that risk of developing CVST blood clots is eight to 10 times higher following a COVID-19 infection as compared to the risk associated with receipt of a COVID-19 vaccine. While national news coverage has focused on reports of the CVST blood clot/stroke condition  cerebral venous sinus thrombosis  following vaccination, the report, published in the journal Stroke, puts the risk in perspective. COVID-19 infection is a significant risk factor for CVST clots.

https://researchnews.cc/news/6792/Rare-blood-clots-more-likely-afte...

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:32pm

Strange Discovery Reveals Prematurely Born Male Babies 'Age' Slightly Faster

As part of the world's longest-running analysis of extremely low birth weight (ELBW) babies born prematurely, scientists have discovered that the genes of male ELBW babies age more quickly than those of full-term male newborns.

We're talking about biological aging or senescence here: these men aren't suddenly rushing through their birthdays at an accelerated rate, but rather hundreds of key genes in their bodies have a greater degree of the kind of chemical editing that occurs naturally over time.

The study results indicated them to be an average of 4.6 years 'older' by their 30s than boys with normal birth weight born at the same time.

The difference wasn't found in female ELBW babies, the researchers report, matching up with previous research that has shown premature male babies may be more sensitive to prenatal stress than premature females.

https://pediatrics.aappublications.org/content/early/2021/05/13/ped...

https://www.sciencealert.com/prematurely-born-male-babies-age-faste...

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:27pm

What if The Heart of The Milky Way Isn't Actually a Black Hole?

All these years we thought there's a blackhole at the centre of our galaxy. 

Now , consider this....

What if it's not a black hole at all? What if it's a core of dark amtter? According to a new and fascinating study, those observed orbits of the galactic center, as well as the orbital velocities in the outer regions of the galaxy, might actually be easier to explain if it was a core of dark matter at the heart of the galaxy, rather than a black hole.

https://arxiv.org/abs/2105.06301

https://www.sciencealert.com/wild-new-paper-proposes-the-center-of-...

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:12pm

Part 2:

In the past 20 years, new coronaviruses have emerged from animals with remarkable regularity. In 2002, SARS-CoV jumped from civets into people. Ten years later, MERS emerged from camels. Then in 2019, SARS-CoV-2 began to spread around the world.

For many scientists, this pattern points to a disturbing trend: Coronavirus outbreaks aren't rare events and will likely occur every decade or so.

Now, scientists are reporting that they have discovered what may be the latest coronavirus to jump from animals into people. And it comes from a surprising source: dogs.

Researchers found evidence of an entirely new coronavirus associated with pneumonia in hospitalized patients — mostly in kids. This virus may be the eighth coronavirus known to cause disease in people, the team reports  in the journal Clinical Infectious Diseases.

The patients had what looked like regular pneumonia. But in eight out of 301 samples tested, or 2.7%,it was  found that the patients' upper respiratory tracts were infected with a new canine coronavirus, i.e., a dog virus.

That's a pretty high prevalence of a [new] virus. Canine coronaviruses were not thought to be transmitted to people. It's never been reported before.

Researchers, after thorough examination, did discover a very, very unique mutation — or deletion — in the genome .That specific deletion, isn't present in any other known dog coronaviruses, but it is found somewhere else: in human coronaviruses. It's a mutation that's very similar to one previously found in the SARS coronavirus and in [versions of] SARS-CoV-2 ... [that appeared] very soon after its introduction into the human population.

This deletion, scientists think helps the dog virus infect or persist inside humans. And it may be a key step required for coronaviruses to make the jump into people.

There's no evidence yet of transmission from human to human.

And in order to stop a future coronavirus pandemic, he says, scientists need to do more testing in people and seek out these strange, hidden infections — before they become a problem.

https://www.npr.org/sections/goatsandsoda/2021/05/20/996515792/a-ne...

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 12:06pm

New Coronavirus Detected In Patients At Malaysian Hospital; The Source May Be Dogs

A new coronavirus might be from dogs

Eight people hospitalized with pneumonia in Malaysia several years ago had evidence of infection with a coronavirus that might have been caugh.... A test designed to detect all coronaviruses — even unknown ones — picked up the genetic signature of a canine coronavirus in samples from the people. It’s the first time that a canine coronavirus — which the researchers have named CCoV-HuPn-2018 — has been found in a person with pneumonia. It is not known whether the virus caused the people’s illness, and there’s no evidence that it can pass from person to person. If it is confirmed that the virus causes disease in humans, it will be the eighth unique coronavirus known to do so; others include those that cause some common colds, and SARS-CoV-2, which causes COVID-19.

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 9:59am

Widely used herbicide linked to preterm births

Exposure to a chemical found in the weed killer Roundup and other glyphosate-based herbicides is significantly associated with preterm births, according to a new University of Michigan study.

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 9:16am

Comment by Dr. Krishna Kumari Challa on May 21, 2021 at 9:05am

Now, white fungus, which is more dangerous than black fungus, hit India - Who are more at risk?

White Fungus infection is more dangerous than black fungus infection because it affects lungs as well as other parts of the body.

Amid the rising cases of Black Fungus infection in several states of India, four cases of White Fungus infection have been reported from Patna in Bihar. It is to be noted that White Fungus is considered more dangerous than Black Fungus. One of the infected patients is a famous doctor from Patna.

White Fungus infection is more dangerous than black fungus infection because it spreads rapidly and  affects lungs as well as other parts of the body including nails, skin, stomach, kidney, brain, private parts and mouth.

Doctors said that white fungus also infect the lungs and an infection similar to COVID-19 is detected when HRCT is performed on the infected patient.  

Patients of white fungus show Covid-like symptoms but test negative; the infection can be diagnosed through CT-Scan or X-ray.

All the four persons infected by White Fungus showed coronavirus-type symptoms but they were not COVID-19 positive. Singh added that but there lungs were found infected and after tests when they were given anti-fungal medicines then they recovered.

Just like Black Fungus, White Fungus is also more dangerous for those who have weak immunity. Diabetes patients and those who are taking steroids for a long period of time are more at risk of getting infected with White Fungus.

COVID-19 patients are more prone to white fungus as it affects the lungs and similar symptoms are created like that of coronavirus.

“Those who have weak immunity like diabetes, cancer patients, and those who are taking steroids for a long period of time must take special care as they are more at risk. It is also affecting those coronavirus patients who are on oxygen support.

Additionally, the white fungus infection may be risky for pregnant women and children, as per reports. Hence, proper emphasis should be laid on sanitization and cleaning of supplies, environment, since molds can be directly inhaled by a suspected patient.

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