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Comment by Dr. Krishna Kumari Challa on July 27, 2021 at 12:39pm

A Lagoon in Argentina Turned Bright Pink, But This Time The Reason Is Unnatural

A lagoon in Argentina's southern Patagonia region has turned bright pink in a striking, but frightful phenomenon experts and activists blame on pollution by a chemical used to preserve prawns for export.

The color is caused by sodium sulfite, an anti-bacterial product used in fish factories, whose waste is blamed for contaminating the Chubut river that feeds the Corfo lagoon and other water sources in the region, according to activists.

Residents have long complained of foul smells and other environmental issues around the river and lagoon.

Environmental engineer and virologist Federico Restrepo told AFP the coloration was due to sodium sulfite in fish waste, which by law, should be treated before being dumped.

https://www.sciencealert.com/prawn-chemical-turns-argentina-lake-br...

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Comment by Dr. Krishna Kumari Challa on July 27, 2021 at 11:52am

Innovative Gene Therapy ‘Reprograms’ Cells to Reverse Neurological Deficiencies

Comment by Dr. Krishna Kumari Challa on July 27, 2021 at 11:45am

COVID-19 immunity varies among genders and age groups

As experts continue to learn more about immune responses to COVID-19 and the effectiveness of vaccines, researchers.

 indicates that the level of antibodies changes according to age groups, gender, symptoms, and time elapsed since vaccination. The findings are the latest from the researchers in a series of studies aimed at providing reliable measures on the effectiveness of COVID-19 vaccination. The new study examined the level of antibodies in over 26,000 blood samples taken from COVID-19 convalescents, as well as vaccinated and unvaccinated individuals. In vaccinated individuals, the researchers found differences between women and men in the concentration of antibodies in the blood relative to both age and gender.

In women, the level of antibodies begins to rise from the age of 51, and is higher than the levels found in men of similar age. This phenomenon may be related change in levels of the estrogen hormone, observed around this age, which affects the immune system. In men, a rise in antibody levels is seen at an earlier age, starting around 35, and may be related to changes in levels of testosterone and the effect on the immune system.

In young adults, a high concentration of antibodies generally signals a strong healthy functioning immune response, while in older demographics it typically indicates overreaction of the immune system associated with severe illness. In general, young adults were found to have a higher level of antibodies sustained for a longer period of time compared to older vaccinated persons. The findings further validate existing evidence that, depending on age, higher antibody count isn't necessarily equivalent to higher rates of recovery.

Furthermore, the study found that the immune response of vaccinated individuals (after two doses) is much stronger than that of people who have recovered from COVID-19. The findings show that vaccinated individuals have four times the level of antibodies compared to convalescents.

https://www.medrxiv.org/content/10.1101/2021.07.07.21259499v1

https://english.tau.ac.il/news/covid_immunity_varies

Comment by Dr. Krishna Kumari Challa on July 27, 2021 at 11:20am

Plastic accumulation in food may be underestimated

A new study has found plastic accumulation in foods may be underestimated. There is also concern these microplastics will carry potentially harmful bacteria such as E. coli, which are commonly found in coastal waters, up the food chain.

Researchers  tested a theory that microplastics covered in a biofilm coating (much like natural algae) were more likely to be ingested by oysters than microplastics that were completely clean. Although the experiment was carried out on oysters under laboratory conditions, scientists believe similar results could be found in other edible marine species that also filter seawater for food.

Up until now, studies to test the impacts of microplastics on marine life have typically used clean, virgin microplastics. However, this is not representative of what happens to microplastics in the marine environment. Bacteria readily colonize microplastics that enter the ocean. In this study, published in Science of the Total Environment, scientists compared the uptake rates of clean microplastics versus microplastics with an E.coli biofilm coating. The results were worrying—oysters contained 10 times more microplastics when exposed to the biofilm coated beads. It is hypothesized that these coated MPs appeared to be more like food to the oysters, explaining their preferential ingestion over clean microplastics.

The scientists say the implications for the food chain are concerning. The ingestion of microplastics is not only bad for the oysters, but it affects human health too. The plastic does not break down in the marine animal and is consumed when we eat it.

The findings in this research give us further insight into the potential harm microplastics are having on the food chain. It demonstrates how we could be vastly underestimating the effect that microplastics currently have. It is clear that further study is urgently needed.

Monica Fabra et al, The plastic Trojan horse: Biofilms increase microplastic uptake in marine filter feeders impacting microbial transfer and organism health, Science of The Total Environment (2021). DOI: 10.1016/j.scitotenv.2021.149217

https://phys.org/news/2021-07-plastic-accumulation-food-underestima...

Comment by Dr. Krishna Kumari Challa on July 27, 2021 at 11:03am

Through the thin-film glass, researchers spot a new liquid phase

Research published in the Proceedings of the National Academy of Sciences describes a new type of liquid in thin films, which forms a high-density glass. Results generated in this study, conducted by researchers in Penn's Department of Chemistry, demonstrate how these glasses and other similar materials can be fabricated to be denser and more stable, providing a framework for developing new applications and devices through better design.

To make better glasses, researchers have used vapor deposition instead of cooling a liquid to produce a glass. In vapor deposition, a material is changed from a gas into a solid directly. While this method has allowed researchers to create denser types of bulk glasses, it was initially thought that thin glass films made using this method would still have the same liquid-like properties that would lead to degradation and instability.

After running all of the control experiments needed, the researchers were surprised to find that when using vapor deposition, they could access a different type of liquid, with a phase transition to the typical bulk liquid upon heating. A phase transition is when a material changes from from one state (gas, liquid, or solid) into another. "The two liquids have distinct structures, akin to graphene and diamond which are both solids made of carbon but exist in very different solid forms.

There are a lot of interesting properties that came out of nowhere, and nobody had thought that in thin films you would be able to see these phases. It's a new type of material.

Yi Jin el al., "Glasses denser than the supercooled liquid," PNAS (2021). www.pnas.org/cgi/doi/10.1073/pnas.2100738118

https://phys.org/news/2021-07-thin-film-glass-liquid-phase.html?utm...

Comment by Dr. Krishna Kumari Challa on July 26, 2021 at 10:14am

Surfing science: Dependent on weather, defined by the ocean

Serious wave chasers are by default atmospheric science junkies because there are few, if any, sports that are both dependent on an uncontrollable variable—the weather—and defined by a literal uneven playing field—the ocean.

Waves are created by the way the swells interact with the bottom contours of the ocean, called the break. Beach breaks—like the Olympic site at Tsurigasaki beach—happen because of sandbars, which can shift over time or due to storms.

Competitive surfing in a nutshell is about deciding which wave to take and what move or moves make the best use of what the ocean delivers. Surfers have to remain prepared and continuously observe the waves for their best guess of what wave they will get to ride.

https://phys.org/news/2021-07-surfing-science-weather-ocean.html?ut...

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Comment by Dr. Krishna Kumari Challa on July 26, 2021 at 10:00am

15,000-year-old viruses discovered in Tibetan glacier ice

Scientists who study glacier ice have found viruses nearly 15,000 years old in two ice samples taken from the Tibetan Plateau in China. Most of those viruses, which survived because they had remained frozen, are unlike any viruses that have been cataloged to date.

The findings, published today in the journal Microbiome, could help scientists understand how viruses have evolved over centuries. For this study, the scientists also created a new, ultra-clean method of analyzing microbes and viruses in ice without contaminating it.

The researchers analyzed ice cores taken in 2015 from the Guliya ice cap in western China. The cores are collected at high altitudes—the summit of Guliya, where this ice originated, is 22,000 feet above sea level. The ice cores contain layers of ice that accumulate year after year, trapping whatever was in the atmosphere around them at the time each layer froze. Those layers create a timeline of sorts, which scientists have used to understand more about climate change, microbes, viruses and gasses throughout history.

Researchers determined that the ice was nearly 15,000 years old using a combination of traditional and new, novel techniques to date this ice core.

When they analyzed the ice, they found genetic codes for 33 viruses. Four of those viruses have already been identified by the scientific community. But at least 28 of them are novel. About half of them seemed to have survived at the time they were frozen not in spite of the ice, but because of it.

These viruses have signatures of genes that help them infect cells in cold environments—just surreal genetic signatures for how a virus is able to survive in extreme conditions.

Zhi-Ping Zhong et al, Glacier ice archives nearly 15,000-year-old microbes and phages, Microbiome (2021). DOI: 10.1186/s40168-021-01106-w

https://phys.org/news/2021-07-year-old-viruses-tibetan-glacier-ice....

Comment by Dr. Krishna Kumari Challa on July 25, 2021 at 10:11am

‘Ancient RNA virus epidemics occurred frequently during human evolution’

• Genome adaptations may offer insight into a viral epidemic as far back as 25,000 years.
• Several lines of evidence point to a coronavirus or similar virus that emerged among the ancestors of East Asian people.
• Identifying ancient viral activity may uncover the potential of evolutionary genomic methods to predict and combat future pandemics.

https://www.sciencedirect.com/science/article/pii/S0960982221007946#!

https://www.medicalnewstoday.com/articles/ancient-rna-virus-epidemi...

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Comment by Dr. Krishna Kumari Challa on July 25, 2021 at 10:08am

How Carbon Capture Works

Comment by Dr. Krishna Kumari Challa on July 25, 2021 at 10:05am

Scientists reverse age-related memory loss in mice

In a study published in Molecular Psychiatry,  a research team show that changes in the extracellular matrix of the brain scaffolding around nerve cells  lead to loss of memory with ageing, but that it is possible to reverse these using genetic treatments. Recent evidence has emerged of the role of perineuronal nets (PNNs) in neuroplasticity  the ability of the brain to learn and adapt  and to make memories. PNNs are cartilage-like structures that mostly surround inhibitory neurons in the brain. Their main function is to control the level of plasticity in the brain. They appear at around five years old in humans, and turn off the period of enhanced plasticity during which the connections in the brain are optimised. Then, plasticity is partially turned off, making the brain more efficient but less plastic. PNNs contain compounds known as chondroitin sulphates. Some of these, such as chondroitin 4-sulphate, inhibit the action of the networks, inhibiting neuroplasticity; others, such as chondroitin 6-sulphate, promote neuroplasticity. As we age, the balance of these compounds changes, and as levels of chondroitin 6-sulphate decrease, so our ability to learn and form new memories changes, leading to age-related memory decline.

They investigated whether manipulating the chondroitin sulphate composition of the PNNs might restore neuroplasticity and alleviate age-related memory deficits.

To do this, the team looked at 20-month old mice – considered very old – and using a suite of tests showed that the mice exhibited deficits in their memory compared to six-month old mice.

For example, one test involved seeing whether mice recognised an object. The mouse was placed at the start of a Y-shaped maze and left to explore two identical objects at the end of the two arms. After a short while, the mouse was once again placed in the maze, but this time one arm contained a new object, while the other contained a copy of the repeated object. The researchers measured the amount of time the mouse spent exploring each object to see whether it had remembered the object from the previous task. The older mice were much less likely to remember the object.

The team treated the ageing mice using a ‘viral vector’, a virus capable of reconstituting the amount of 6-sulphate chondroitin sulphates to the PNNs and found that this completely restored memory in the older mice, to a level similar to that seen in the younger mice.

1. Sujeong Yang, Sylvain Gigout, Angelo Molinaro, Yuko Naito-Matsui, Sam Hilton, Simona Foscarin, Bart Nieuwenhuis, Chin Lik Tan, Joost Verhaagen, Tommaso Pizzorusso, Lisa M. Saksida, Timothy M. Bussey, Hiroshi Kitagawa, Jessica C. F. Kwok, James W. Fawcett. Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing. Molecular Psychiatry, 2021; DOI: 10.1038/s41380-021-01208-9

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