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Comment by Dr. Krishna Kumari Challa 47 minutes ago

128 New Moons Found Orbiting Saturn

The race between Jupiter and Saturn for the most moons in the Solar System may have just finally come screeching to a halt.

A team of scientists has found a whopping 128 previously unknown moons hanging around Saturn, in a discovery officially recognized by the International Astronomical Union. This brings the planet's total number of known moons to 274, leaving Jupiter, with its mere 95 moons, in the dust.

https://arxiv.org/abs/2503.07081

Comment by Dr. Krishna Kumari Challa 3 hours ago

Mosquito pain receptors found to be less sensitive during extreme heat, which could nullify some natural bug sprays

Hotter temperatures may render natural insect repellents less effective against mosquitoes, according to a new study. Researchers found that a pain receptor called TRPA1 becomes less sensitive in mosquitoes when exposed to heat, meaning that the chemical cues that typically trigger insect avoidance behaviors are prevented from activating as strongly.

TRPA1, also known as the "wasabi receptor," helps animals detect noxious heat and harmful chemicals. In humans, this receptor can induce eye and skin irritation. In mosquitoes, it influences which hosts the insects find most alluring—specifically, those unprotected by repellents that drive them away.

What the researchers now  found was that the chemicals were not able to activate the mosquito wasabi receptor as effectively when temperatures exceeded the heat activation threshold.

Typical insect repellents create a chemical barrier that discourages proximity and prevents mosquitoes from reaching their target. Yet because their receptors are desensitized in warmer temperatures, natural substances like citronellal and catnip oil, known for their repellent properties, would be less effective. Products with those ingredients may be less effective if you're using them at temperatures that are considered extreme heat events, say the researchers.

Yeaeun Park et al, Heat activation desensitizes Aedes aegypti transient receptor potential ankyrin 1 (AaTRPA1) to chemical agonists that repel mosquitoes, Pesticide Biochemistry and Physiology (2025). DOI: 10.1016/j.pestbp.2025.106326

Comment by Dr. Krishna Kumari Challa 4 hours ago

Food insecurity raises risk of heart disease over time: A 20 year study

Struggling to afford food today could mean heart problems tomorrow. Young adults experiencing food insecurity have a 41% greater risk of developing heart disease in midlife, even after accounting for demographic and socioeconomic factors, according to a new  Medicine study.

Food insecurity means struggling to get enough nutritious food to stay healthy.

That makes it a clear target for prevention—if we address food insecurity early, we may be able to reduce the burden of heart disease later."

The study was published in JAMA Cardiology.

Among the 3,616 study participants, those experiencing food insecurity were 41% more likely to develop cardiovascular disease than their food-secure counterparts. Over the study period, 11% of food-insecure individuals developed heart disease, compared to 6% of those with adequate food access.

By following people over two decades, researchers were able to show that food insecurity, on its own, significantly increases the risk of developing cardiovascular disease. 

 Food Insecurity and Incident Cardiovascular Disease Among Black and White US Individuals, 2000-2020, JAMA Cardiology (2025). DOI: 10.1001/jamacardio.2025.0109

Comment by Dr. Krishna Kumari Challa 4 hours ago

Cells 'speed date' to find their neighbours when forming tissues

In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one that falters.

A study published in the Biophysical Journal demonstrates how heart cells go about this "matchmaking" process. The researchers model the intricate movements of these cells and predict how genetic variations could disrupt the heart development process in fruit flies.

In both humans and fruit flies, the heart's tissues arise from two distinct regions of the embryo, which are initially far apart. As development progresses, these cells journey toward each other, ultimately merging into a tube-like shape that will become the heart. For the heart to develop correctly, these cells must align and pair up precisely.

As the cells come together, they jiggle and adjust, and somehow always end up pairing with a heart cell of the same type. This observation inspired researchers to explore how cells match up in the first place and how they know when they've found the right fit.

Developing heart cells have tentacle-like protrusions called filopodia, which probe and grab onto potential partners.

Earlier researchers found that proteins create waves that pull mismatched cells apart, giving them another chance to find the right match.

It's basically like cells are speed dating. They have just a few moments to determine if they're a good match, with molecular 'friends' ready to pull them apart if they're not compatible.

The researchers found that heart cells seek stability where they remain closest to stillness—like a rolling ball that eventually comes to a stop, known as energy equilibrium in physics.

In developing heart cells, this principle applies when cells find a balance between connection forces and their ability to adjust to strain—also known as adhesive energy and elasticity. Based on this observation, the team developed a model that shows how cells can self-organize.

Scientists tested their model on fruit fly hearts with mutations and misalignments. By calculating the adhesive energy between different cell types and assessing tissue elasticity, the model predicted how cells would match and rearrange.

Although rare, sometimes the heart tube ends up with one cell on one side when it should have two, or two cells when there should be four. The model produced outcomes that closely mirrored what was observed in real embryos.

This  new model not only enhances our understanding of how cells match and align during heart development but also has broader applications. Similar cell-matching processes are crucial in neuronal connections, wound repair, and facial development, where hiccups can lead to conditions like cleft lip.

Interfacial energy constraints are sufficient to align cells over large distances, Biophysical Journal (2025). DOI: 10.1016/j.bpj.2025.02.011

Comment by Dr. Krishna Kumari Challa 6 hours ago

When somebody says 'shut up!', how do you stop speaking?

A premotor cortical network in the brain allows people to voluntarily stop speaking, study suggests

Speech is a unique human ability that is known to be supported by various motor and cognitive processes. When humans start speaking, they can decide to cease at any point; for instance, if they are interrupted by something happening or by another person speaking to them.

The ability to voluntarily stop speaking plays a central role in social interactions, as it allows people to engage in conversations with others while adaptively responding to social cues, environmental stimuli or interruptions.

Researchers  recently set out to better understand how the human brain controls the ceasing of speech using tools to record neurophysiological signals. Their paper, published in Nature Human Behaviour, unveils a previously unknown premotor cortical network that could support voluntary speech inhibition.

Researchers recruited 13 patients diagnosed with treatment-resistant epilepsy who had electrodes implanted on their brains' surfaces to better understand the brain regions that contribute to their epileptic seizures. These patients were asked to complete a speech-stopping task, which asked them to follow instructions on when to start and stop speaking, while their neural activity was recorded.

Neural recordings revealed distinct activity in the premotor frontal cortex correlated with stopping speech. This activity was found in largely separate cortical sites from regions encoding vocal tract articulatory movements. Moreover, this activity primarily occurred with abrupt stopping in the middle of an utterance, rather than naturally completing a phrase.

The findings gathered by this team of researchers hint at the existence of a specialized brain mechanism that supports the voluntary control of speech.

The researchers conducted further tests aimed at validating the existence of this mechanism by stimulating specific parts of the premotor frontal cortex.

Electrocortical stimulation at many premotor sites with inhibitory stop activity caused involuntary speech arrest, which contradicts previous clinical interpretations of this effect as evidence for critical centers of speech production," wrote the team in their paper. "Together, these results suggest a previously unknown premotor cortical network that supports the inhibitory control of speech, providing implications for understanding both natural and altered speech production."

Overall, the results of this study suggest that the human ability to voluntarily stop speech is supported by a particular inhibitory control neural network that had not been uncovered before.

Lingyun Zhao et al, Inhibitory control of speech production in the human premotor frontal cortex, Nature Human Behaviour (2025). DOI: 10.1038/s41562-025-02118-4

Comment by Dr. Krishna Kumari Challa yesterday

Turtle Dance
Researchers found that the turtles exhibited significantly higher levels of ‘turtle dance’ behaviour when they were in their designated feeding fields, strongly suggesting that they could distinguish between the two magnetic fields.

Comment by Dr. Krishna Kumari Challa yesterday

A 'Yellow Brick Road' at The Bottom of The Pacific Ocean

An example of ancient active volcanic geology!

Comment by Dr. Krishna Kumari Challa yesterday

Coma brain waves hint at who’s waking up

A pattern of brain waves that occurs during sleep might help to predict whether an unresponsive person who experienced severe brain.... Researchers recorded the electrical activity in the brains of 226 people in a coma who had experienced recent brain injury, and homed in on a specific patterns of brain activity called sleep spindles. They found that 28% of people who had well-defined sleep spindles recovered consciousness, compared with only 14% of those who lacked this pattern. “We're starting to lift the lid a little bit and find some signs of recovery as it's happening,” says neurologist and study co-author Jan Claassen.

ScienceAlert
Reference: Nature Medicine paper

Comment by Dr. Krishna Kumari Challa yesterday

bioRxiv and medRxiv make it official

A new chapter has begun for two of the world’s most popular preprint platforms, bioRxiv and medRxiv, with the launch of a non-profit organization that will manage them. openRxiv, which will have a board of directors and a scientific and medical advisory board, takes over from Cold Spring Harbor Laboratory in New York. It has “become so important that they should have their own organization running them, which is focused on the long-term sustainability of the servers, as opposed to being a side project within a big research institution,” says Richard Sever, the co-founder of both servers.

Nature | 

Preprint sites bioRxiv and medRxiv launch new era of independence

The popular repositories, where life scientists post research before peer review, will be managed by a new organization called openRxiv.

https://www.nature.com/articles/d41586-025-00762-4?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa yesterday

Microplastics may threaten global food supply by disrupting photosynthesis

A team of environmental researchers, Earth scientists and pollution specialists  has found evidence that microplastics have a negative impact on photosynthesis in terrestrial, marine, and freshwater ecosystems.

In their study, published in the Proceedings of the National Academy of Sciences, the group conducted a meta-analysis of data from more than 150 studies involving the impact of microplastics on plants.

Prior research has shown that microplastics have made their way to nearly every ecosystem on the planet, and now contaminate plants and animals, including humans. For this new study, the research team wondered if microplastics might have an unknown impact on plants living in the ocean, in fresh water or growing on land, and they conducted a study of prior research to find out.

The team suspected that microplastics might have a direct impact on the ability of plants to engage in photosynthesis. To that end, they searched the literature using an AI app and found 157 studies that mentioned both microplastics and impacts on photosynthesis, which included 3,286 observations.

Combining the results, the researchers calculated that microplastics reduced photosynthetic efficiency across all three plant types by 7% to 12% and caused reductions in production of chlorophyll. Such percentages, they suggest, result in approximately 4% to 14% harvest yield losses of maize, wheat and rice around the globe. They also suggest that microplastics account for up to 7% of losses in global aquatic net primary productivity.

The research team notes that the problem appears to be worsening, which will impact crop production even more. They further suggest that if the problem is not reversed, the result could be a major increase in the number of people at risk of starvation over the next two decades.

 Ruijie Zhu et al, A global estimate of multiecosystem photosynthesis losses under microplastic pollution, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2423957122

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