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Comment by Dr. Krishna Kumari Challa 8 hours ago

The researchers say the next step for this work is to understand what causes changes in the immune system between the onset of infection and the development of sepsis. Understanding these changes could help identify new treatment targets and approaches to reduce either progression to sepsis or the severity of sepsis, with the potential to improve outcomes and make a difference in the lives of millions affected by serious infections worldwide.

Temporal Analyses of Immune Responses in Sepsis Reveal Asynchrony Between Clinical stage of illness and Immune State, Immunity (2026). DOI: 10.1016/j.immuni.2026.08.003. www.cell.com/immunity/fulltext … 1074-7613(26)00325-0

Part 2

Comment by Dr. Krishna Kumari Challa 8 hours ago

Three shifting immune states in sepsis could explain why treatments miss their window
Researchers have mapped how the immune response in people with sepsis changes over time. The work could help pave the way for treatments that target the specific parts of the immune system that are altered over the time course (trajectory) of sepsis illness in adults.

Sepsis is a life-threatening condition that occurs when the immune response to infection misfires. In sepsis, vital organs fail, and the condition can be fatal even when treated quickly. It's estimated that there are over 160 million cases and about 21 million deaths from sepsis worldwide each year.

Current treatments for sepsis focus on treating the underlying infection with antimicrobials and providing supportive care for failing vital organs. Despite efforts to treat the misfiring immune system, none have successfully improved outcomes for patients.

In the new study, published this week in Immunity, researchers sought a more detailed understanding of the immune response mechanisms that change over time in patients with sepsis.

They analyzed blood samples collected at four different time points (between admission to and discharge from critical care) from critically ill patients with sepsis . To build a detailed picture of the immune response, called an "immune profile," the researchers examined multiple layers of immune response information in the blood samples, including data on immune cells, gene expression and changing protein expression.

Using machine learning approaches, they then combined these layers of information to generate a more comprehensive immune profile for the first time in patients with sepsis.
The analyses revealed an immune trajectory with three distinct temporal immune states (referred to as STImS) between admission and recovery, with each state involving different immune cell activity and immune response programs.

Importantly, these sepsis immune states didn't match the clinical stage of sepsis. For example, the "early" immune state (STImS1) was not the same as the early clinical stage of sepsis, which is often the day a clinician diagnoses sepsis.

The researchers say these findings could have important implications for determining how best to treat patients with sepsis—specifically, which treatments to use and when.

The main aim of this work was to build a profile of sepsis immune responses over time. When people are admitted to a hospital with sepsis, they are usually classed as having 'early' sepsis—but the new findings show that this isn't necessarily the case—their immune system may already be at later stages of the immune response. Knowing exactly what is happening to a patient's immune system during sepsis could identify which treatments are likely to work best.
This research shows the importance of looking at the changing architecture of the immune system in sepsis over time, rather than just taking a snapshot view. We need to find better ways to treat the misfiring immune system. Only by understanding the intricacies of the immune system in all its component parts—by integrating and dynamically mapping cell and molecular immunobiology to determine why the very system designed to protect us from infections is misfiring in sepsis—can we begin to improve outcomes for patients by treating the misfiring immune system, say the researchers.
part 1

Comment by Dr. Krishna Kumari Challa 9 hours ago

Can total joint replacement particles reach the brain?
Total joint replacement is a proven treatment to relieve chronic knee pain, but concerns have been raised that particles from the device may migrate to the brain and cause memory problems. New research from Rush University shows this may not be a concern.
In 701 deceased older adults, implant-derived wear particles were detected in brains of some people with joint replacements but were not associated with cognitive decline. Cobalt exposure was associated with greater Alzheimer disease pathology, particularly raising concern for hip implants with accelerated wear.

In a study published in Acta Biomaterialia, researchers found that particles in some people with total joint replacements traveled to the brain but did not cause cognitive decline.

Researchers did find an association between cobalt, a key element in most implants, and greater Alzheimer's disease pathology in the brain.

The particles, called wear debris, are caused by friction and movement in the joint or, in some cases, corrosion. The newer materials used in joint replacements today make this less likely to occur.

Implants have a very specific combination of metals such as cobalt, and when they show up together in one particle in the brain in the exact same composition that the implant is, we know it can't come from any other source.
For years, we've known that particles can deposit in tissues surrounding the joint, but this is the first study to look at the particles deposited in the brain.
Total joint arthroplasty remains one of the most successful and life-changing interventions in modern medicine. But it does suggest that wear particles from the implant, particularly in certain hip replacements involving accelerated wear, may travel beyond the joint and warrant further study, say the researchers.

Robin Pourzal et al, Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement, Acta Biomaterialia (2026). DOI: 10.1016/j.actbio.2026.05.006

Comment by Dr. Krishna Kumari Challa 10 hours ago

Hitting bacteria hard and early with diverse phage cocktails may curb resistance

As multidrug antibiotic resistance emerges as a potent public health challenge, medical science has renewed attention on the potential for bacteriophage therapy. Bacteriophages, or phages, are viruses that target, infect and replicate inside bacteria, destroying them in the process. To help maximize the success rate of this approach, researchers recently modeled the dynamics of bacteriophage therapy to explain particular therapies and optimize the composition of bacteriophage cocktails.

Phage are the most prevalent organisms on the planet. They exist everywhere bacteria exist. However, each phage has evolved to narrowly target specific bacteria, and bacteria have evolved various mechanisms of resistance.
Phage cocktails—combinations of particular phages for a patient facing a specific bacterial infection—represent a complicated form of personalized medicine. Given the fast and complex dynamics of bacterial responses to phages, it is not typically known why a particular phage therapy succeeded or failed. As described in the journal PLOS Computational Biology, the research team developed a mathematical model that could describe effective phage cocktails and optimize their diversity and timing.
The researchers developed their mathematical model by building on an existing model calibrated with data from phage therapy in a live mouse. The mathematical model was extended to humans and included multiple phages infecting multiple bacterial strains with varying phage resistance.
The model was able to predict success based on several key factors. The bacteria's pretreatment resistance level was critical, as were the diversity of the phage cocktail and the timing of its delivery. Phage therapy is a complicated dynamic in which more infective phages can wipe out more sensitive (i.e., less resistant) bacteria faster. That leaves resistant bacteria to expand, and they can quickly evolve better resistance, mutating to avoid infection by the phage.

The team found that therapy is best served by a diversity of phages, which overwhelm the bacteria's ability to evolve resistance quickly enough. The team also focused on the timing of phage delivery, determining that immediate treatment with the full phage cocktail offered the most success. That creates a high genetic barrier to bacterial resistance, meaning that the bacteria would need to accumulate several genetic changes or mutations to survive the therapy.
The rapid evolution of resistance is the main challenge to therapy.
That capacity is why antibiotics may not work in the first place. For phage therapy to be effective, the cocktails should be diverse, sufficient and immediate. The approach amounts to 'hit the bacteria hard and early.

Rob J. de Boer et al, Towards modeling phage therapy, PLOS Computational Biology (2026). DOI: 10.1371/journal.pcbi.1014408

Comment by Dr. Krishna Kumari Challa 10 hours ago

During natural rock weathering, silicate minerals like olivine dissolve to release primarily magnesium (Mg), iron (Fe) and silicate (SiO4), trapping atmospheric CO2 in the water as bicarbonate (HCO3-).

MgFeSiO4 + 4CO2 + 4H2O → Mg2+ + Fe2+ + H4SiO4 + 4HCO3−

Specifically, the released iron is not soluble when exposed to the atmosphere. Instead, it covers the mineral surface as rust, slowing down the entire process.

4Fe2+ + 3O2 → Fe2O3 (rust)

By producing siderophores, bacteria can capture, solubilize and take up oxidized (rusted) iron to sustain their own growth. Conveniently, this effectively derusts the mineral surface, speeding up rock weathering.

Researchers used custom bioreactors to tease apart when natural bacteria produce siderophores. They found that even a small amount of iron-containing mineral completely inhibited siderophore production, posing a major problem for siderophore production at an industrial scale.
Once wild bacteria have enough iron to grow, they stop making siderophores completely. To enable enhanced weathering at scale, the researchers engineered A. macleodii to always produce siderophores. They essentially decoupled siderophore production from environmental iron levels.
This way they succeeded in achieving their goal.

Neil C. Dalvie et al, Engineered bacterial siderophore production accelerates rock weathering for carbon removal, Nature Biotechnology (2026). DOI: 10.1038/s41587-026-03288-w. On bioRxiv: www.biorxiv.org/content/10.110 … .04.08.647837v2.full

Part 2

Comment by Dr. Krishna Kumari Challa 10 hours ago

Engineered bacteria offer a new way to accelerate rock weathering for carbon removal

Rock weathering, the breakdown and dissolving of rocks and minerals caused by their exposure to water, air and biological life, is a major regulator of Earth's atmospheric CO2 levels and climate. Throughout Earth's history, rock weathering has been faster during warm periods with increased atmospheric CO2 levels.
Dissolved minerals ultimately wash into the ocean, where they draw CO2 from the atmosphere and cool the planet again. While this thermostat is responsible for the temperate climate we enjoy on Earth, the weathering cycle occurs over hundreds of thousands of years.

In search of climate solutions, scientists have asked whether the rock weathering cycle could be sped up, resulting in a number of new companies pursuing enhanced rock weathering (ERW).

By scattering crushed silicate rocks on agricultural surfaces or into water, they aim to pull excess CO2 out of the atmosphere. Although this strategy is generally safe and environmentally friendly, it is still too slow to affect the global carbon balance or to be economically viable on an industrial scale.
Now a research team has engineered a potential solution to this problem.
The research team genetically engineered Alteromonas macleodii, a widespread marine bacterium, to produce much higher amounts of so-called siderophores, molecules that extract iron from silicate minerals.
In customized bioreactors with a continuous flow of seawater, the engineered bacterium sped up the weathering of the silicate mineral olivine by 2.6-fold, boosting the amount of CO2 removed from the air.
Part 1

Comment by Dr. Krishna Kumari Challa 10 hours ago

Bumblebees may self-medicate when exposed to fungal infections

It's already known that some animals try to heal themselves when ill. For example, wild chimpanzees have been shown to reach for plants with pain-relieving and antibacterial properties, and some birds line their nests with cigarette butts because the chemicals ward off mites. Previous studies have also shown that honey bees with some types of infections collect more protective plant resin.
Now a new study published in the journal Royal Society Open Science suggests that buff-tailed bumblebees (Bombus terrestris) may self-medicate when exposed to a fungal brood disease.

In the experiments conducted, after five days of free foraging, colonies exposed to the fungus Ascosphaera apis became increasingly likely to visit the quercetin-laced flowers and spent more time drinking from them.

However, those exposed to the bacterium Serratia marcescens showed no significant change in their preference for quercetin nectar as the experiment progressed. Colonies from the healthy control group also showed no significant change in their preference for quercetin nectar.

So while the researchers observed a clear behavioral shift toward quercetin nectar, it did not occur for both types of pathogens, suggesting that disease type matters. "Overall, these results indicate that pathogen identity shapes behavioral plasticity in nectar foraging," wrote the study authors in their paper.

However, because the study did not measure whether drinking quercetin actually reduced infection levels or helped more larvae survive, the findings should be treated with caution. The results do not provide a definitive demonstration of formal self- or social medication.

Kamiel Debeuckelaere et al, Hints of self-medication? Pathogen exposure-dependent foraging decisions of bumblebees, Royal Society Open Science (2026). DOI: 10.1098/rsos.260777

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Comment by Dr. Krishna Kumari Challa yesterday

Why do some people react so badly to mosquito bites? The answer lies in mosquito saliva
Mosquito saliva contains anticoagulant and immune-modulating proteins that trigger histamine release and a Th2-type inflammatory response, causing itching, redness, and swelling. Reaction severity varies with immune genetics, age, prior exposure, and mosquito species; hypersensitivity can cause large local reactions. Saliva may also enhance establishment of mosquito-borne infections.

Comment by Dr. Krishna Kumari Challa yesterday

Overuse of inhalers found to increase heart attack risk in asthma and COPD patients

Overuse of reliever inhalers is associated with higher risks of developing and dying from cardiovascular disease, including heart failure, heart attack and ischemic stroke, in patients with asthma and COPD, according to a study published this week in ERJ Open Research.
In asthma and COPD, greater short-acting bronchodilator use was associated with higher cardiovascular disease and mortality risk. Use of ≥3 inhalers annually increased mortality versus ≤2; risks were greater in those without prior cardiovascular disease. Overuse may indicate poorly controlled disease requiring treatment review.
These "reliever" inhalers can help people breathe more easily when their symptoms are particularly bad. However, it is possible to overuse them if a patient's asthma or COPD is not being managed well by "preventer" treatments.
The study assessed real-world data from primary and secondary care for more than 280,000 COPD and asthma patients who used either SABA (short-acting beta-agonist), SAMA (short-acting muscarinic antagonist), both or no short-acting bronchodilators to manage their condition. Researchers took into account differences in age, sex, socioeconomic status, smoking history, nursing home residency, disease severity and other conditions or medications.

Both SABA and SAMA bronchodilators are often used as reliever therapies by asthma and COPD patients. SABA bronchodilators increased the risk of death by 12% and 14% in asthma and COPD patients, respectively, compared with no use. The risk of death from SAMA bronchodilators increased by 73% and 36%, respectively.

The researchers also assessed how the number of inhalers used per year affected cardiovascular health. They found that using three or more inhalers per year for either bronchodilator was associated with an increased risk of death compared with two or fewer inhalers per year. Patients who did not have any prior history of cardiovascular disease were found to be more vulnerable to cardiovascular problems resulting from inhaler overuse.
Overuse of short-acting bronchodilators is an alarm signal that indicates uncontrolled airway inflammation and requires a medical review of treatment. It should prompt patients to have their lungs checked and health care providers to check adherence and inhaler technique against treatment guidelines.
Patients should be informed that short-acting bronchodilators only relax airway muscles briefly. Uncontrolled asthma and COPD are already linked to an increased risk of cardiovascular disease and death. When this is combined with overuse of SABA and SAMA bronchodilators—which both cause faster, irregular heart rates as a side effect—these risks become even more pronounced. Overreliance on this short relief may allow the underlying disease activity to progress unchecked. This research should draw clinicians' attention to the fact that overuse is common and may be associated with adverse effects, even in patients without cardiac history.

Overuse of inhalers found to increase heart attack risk in asthma and COPD patients, ERJ Open Research (2026). DOI: 10.1183/23120541.00462-2026

Comment by Dr. Krishna Kumari Challa yesterday

Electrically charged raindrops could be corroding metal with protective coatings

Water droplets acquire 0.2–2 nC charges after sliding on common natural and synthetic surfaces. After 3,000 charged droplets contacted Teflon-coated copper, the coating degraded and underlying copper corroded; uncharged droplets caused no detectable damage. This mechanism may affect protective coatings on outdoor metal structures.

Zhongyuan Ni et al, Spontaneously charged water drops induce corrosion, Nature (2026). DOI: 10.1038/s41586-026-10941-6

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