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Comment by Dr. Krishna Kumari Challa 18 hours ago

Mitosis, meiosis, or a new different option
Researchers have found a way to prompt a new cell division process to create a viable egg cell from a skin cell. First, they implanted the skin cell’s nucleus into an empty egg. Then, the team induced a process they called ‘mitomeiosis’. This forces the egg to discard one set of chromosomes, which are replaced by that of the sperm during fertilization. Only a few of the resulting embryos developed beyond eight cells, but the research demonstrates the potential of the process for in-vitro fertilization using skin cells, the researchers say.

https://www.reuters.com/business/healthcare-pharmaceuticals/scienti...

Reference: https://www.nature.com/articles/s41467-025-63454-7?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa 19 hours ago

Overall, first responders with elevated CH mutations were nearly six times likelier to develop leukemia than those without the mutations. Exposure of mice to WTC dust led to high levels of inflammatory markers and an increase in mutant cells, suggesting that toxin-induced inflammation plays a key role in propagating the blood cells.

In addition, researchers found that younger first responders (those under age 60) with elevated CH possessed a set of gene mutations quite distinct from the classic mutations associated with age-related CH—indicating that the gene-altering toxins in WTC dust may contribute to cancer risk by accelerating the aging process.
To learn how exposure to toxins is associated with CH mutations and increased leukemia risk, the researchers tested the dust collected from the WTC site in a mouse model.

The dust caused an inflammatory response traced to the protein IL1RAP; the high levels of IL1RAP were associated with increased numbers of defective blood-forming stem cells—mimicking the high CH levels observed in the first responders. Importantly, the researchers found they could prevent the rise in defective mutant cells by knocking out the gene that codes for IL1RAP.
IL1RAP has been implicated in many types of cancer as well as in inflammatory and autoimmune diseases and that several drugs aimed at inhibiting the protein are being evaluated in clinical trials.
By screening toxin-exposed populations for CH, we could identify people at risk for blood cancers and then potentially treat or even prevent those cancers by targeting IL1RAP, say the researchers.

Elevated clonal hematopoiesis in environmentally exposed 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion, Cancer Discovery (2025).

https://www.eurekalert.org/news-releases/1100191

Part 2

Comment by Dr. Krishna Kumari Challa 19 hours ago

9/11 study shows how toxic exposures may lead to blood cancers

A study by researchers has found that mutations in blood-forming cells may explain the increased risk for leukemia and other blood disorders among first responders exposed to the 9/11 World Trade Center (WTC) disaster site and its toxic dust.

The study also points to a novel strategy for use against inflammation and blood disorders associated with environmental toxins. The research is published in Cancer Discovery in a study titled "Elevated clonal hematopoiesis in environmentally exposed 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion."

The findings provide new insights into the long-term health impacts of environmental catastrophes, such as wildfires, and suggest targeted interventions for those affected by 9/11 or similar disasters.

The collapse of the WTC produced tremendous quantities of airborne particulate matter—a potent mixture of carcinogens and genetically toxic substances to which an estimated 400,000 responders, area workers, and residents were exposed.

In previous studies, researchers noted a higher incidence of cancers, cardiovascular disease, and other health problems among 9/11 first responders compared with the general population. However, few studies have examined how such environmental exposures can lead to blood cancers.

For this study,  scientists sequenced blood samples from nearly 1,000 first responders who were exposed to the WTC site, along with blood from two control groups: 255 firefighters who were not at the WTC and 198 unexposed people in the general population.
All samples were collected between December 2013 and October 2015. The toxic 9/11 dust cloud was found to be associated with mutations in the blood cells of many responders.

Compared with control-group individuals, WTC-exposed first responders had a significantly higher prevalence of clonal hematopoiesis (CH)—a condition in which a group, or clone, of a person's blood-forming (hematopoietic) stem cells contain the same gene mutations. Typically associated with aging, CH is a precancerous condition known to increase the risk of blood cancer and inflammation.

Part 1

Comment by Dr. Krishna Kumari Challa 19 hours ago

Rare fossil reveals ancient leeches weren't bloodsuckers

A newly described fossil reveals that leeches are at least 200 million years older than scientists previously thought, and that their earliest ancestors may have feasted not on blood, but on smaller marine creatures.

Roughly 430 million years old, the fossil includes a large tail sucker—a feature still found in modern leeches—along with a segmented, teardrop-shaped body. But one important feature isn't found in this fossil: the forward sucker that many of today's leeches use to pierce skin and draw blood.

This absence, along with the fossil's marine origin, suggests a very different early lifestyle for the group known as Hirudinida. Rather than sucking blood from mammals, reptiles, and other vertebrates, the earliest leeches may have roamed the oceans, consuming soft-bodied invertebrates whole or feeding on their internal fluids.

Blood feeding takes a lot of specialized machinery. Anticoagulants, mouthparts, and digestive enzymes are complex adaptations. It makes more sense that early leeches were swallowing prey whole or maybe drinking the internal fluids of small, soft-bodied marine animals.

Previously, scientists thought leeches emerged about 150–200 million years ago. That timeline has now been pushed back by at least 200 million years, thanks to the fossil found in the Waukesha biota, a geological formation in Wisconsin known for preserving the bodies of soft tissue animals that usually decay before fossilization.

Preserving a leech fossil is no small feat. Leeches lack bones, shells, or exoskeletons that are most easily preserved over millions of years. Fossils like this require exceptional circumstances to preserve, often involving near-immediate burial, a low-oxygen environment, and unusual geochemical conditions.

A rare animal and just the right environment to fossilize it—it's like hitting the lottery twice.

de Carle D, et al. The first leech body fossil predates estimated hirudinidan origins by 200 million years, PeerJ (2025). doi.org/10.7717/peerj.19962

Comment by Dr. Krishna Kumari Challa 19 hours ago

Zoo life reduces—but does not erase—lifespan gaps
A long-standing idea is that environmental pressures—such as predation, pathogens, or harsh climates—drive the observed gaps between males and females. To test this, the researchers turned to zoo populations, where such pressures are largely absent.
They found that lifespan gaps persisted even under these protected conditions. Comparing zoo and wild populations showed that the gaps were often smaller in zoos but rarely disappeared—mirroring the human case, where advances in medicine and living conditions have narrowed but not eliminated the lifespan gap.

The findings suggest that sex differences in lifespan are deeply rooted in evolutionary processes—shaped by sexual selection and parental investment and that genetic differences in the sex determination system may also play a role. Environmental factors influence the extent of the differences, but cannot eliminate them. The differences between the sexes are therefore not only a product of the environment, but part of our evolutionary history, and will most likely continue to exist in the future.

Sexual selection drives sex difference in adult life expectancy across mammals and birds, Science Advances (2025). DOI: 10.1126/sciadv.ady8433

Part 2

Comment by Dr. Krishna Kumari Challa 19 hours ago

Why women live longer than men

Tracing the evolutionary roots of why women live longer than men

Around the world, women on average live longer than men. This striking pattern holds true across nearly all countries and historical time periods. Although the gap between the sexes has narrowed in some countries due to medical advances and improved living conditions, new research now provides clues as to why this difference is unlikely to disappear anytime soon. The causes are deeply rooted in evolutionary history and can be observed in many animal species.

An international team of scientists  conducted the most comprehensive analysis of sex differences in lifespan across mammals and birds to date. Their findings, published in Science Advances, provide novel insight into one of biology's long-standing puzzles: why males and females age differently.

Among mammals, females usually live longer—for instance, in baboons and gorillas, females often outlive males. Yet this pattern is not universal: In many birds, insects, and reptiles, males are the longer-lived sex. One genetic explanation, the heterogametic sex hypothesis, points to differences in sex chromosomes.

In mammals, females have two X chromosomes, while males have only one X and one Y (making them the heterogametic sex). Some research suggests that having two X chromosomes may protect females from harmful mutations, offering a survival advantage. In birds, however, the system is reversed: females are the heterogametic sex.

Using records from over 1,176 bird and mammal species in zoos worldwide, the researchers found a striking contrast in lifespan, supporting the heterogametic sex hypothesis: in most mammals (72 percent), females lived longer, by on average twelve percent, while in most bird species (68 percent), males lived longer, overall by an average of five percent.

Still, there was remarkable variation with many exceptions. Some species showed the opposite of the expected pattern. For example, in many birds of prey, females are both larger and longer-lived than males. So sex chromosomes can only be part of the story.

Sexual selection and parental care shape lifespan differences

In addition to genetics, reproductive strategies also play a role. Through sexual selection, males in particular develop conspicuous characteristics such as colorful plumage, weapons, or large body size, which increase reproductive success but can shorten lifespan. The new study supports this assumption: In polygamous mammals with strong competition, males generally die earlier than females.

Many birds, on the other hand, are monogamous, which means that competitive pressure is lower and males often live longer. Overall, the differences were smallest in monogamous species, while polygamy and pronounced size differences were associated with a more pronounced advantage for females.

Parental care also plays a role. The researchers found evidence that the sex that invests more in raising offspring—in mammals, this is often the females—tends to live longer. In long-lived species such as primates, this is likely to be a selective advantage: females survive until their offspring are independent or sexually mature.

Part 1

Comment by Dr. Krishna Kumari Challa 21 hours ago

Parkinson's 'trigger' directly observed in human brain tissue for the first time

Scientists have, for the first time, directly visualized and quantified the protein clusters believed to trigger Parkinson's, marking a major advance in the study of the world's fastest-growing neurological disease.

These tiny clusters, called alpha-synuclein oligomers, have long been considered the likely culprits for Parkinson's disease to start developing in the brain, but until now, they have evaded direct detection in human brain tissue.

Now, researchers  have developed an imaging technique that allows them to see, count and compare oligomers in human brain tissue, a development one of the team says is "like being able to see stars in broad daylight."

Their results, reported in the journal Nature Biomedical Engineering, could help unravel the mechanics of how Parkinson's spreads through the brain and support the development of diagnostics and potential treatments.

The team examined post-mortem brain tissue samples from people with Parkinson's and compared them to healthy individuals of similar age. They found that oligomers exist in both healthy and Parkinson's brains. The main difference between disease and healthy brains was the size of the oligomers, which were larger, brighter and more numerous in disease samples, suggesting a direct link to the progression of Parkinson's.

The team also discovered a sub-class of oligomers that appeared only in Parkinson's patients, which could be the earliest visible markers of the disease—potentially years before symptoms appear.

Rebecca Andrews et al, Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue, Nature Biomedical Engineering (2025). DOI: 10.1038/s41551-025-01496-4

Comment by Dr. Krishna Kumari Challa 21 hours ago

Microplastics reduce soil fertility and boost production of a potent greenhouse gas, study shows

More than 90% of plastic waste ends up in the soil, where it breaks down into microplastics that are invisible to the naked eye. Microplastic pollution of the soil poses a severe threat to soil health as it can harm essential microbial communities and reduce crop yields. The presence of these tiny plastics may also worsen climate change by boosting the production of greenhouse gases, according to a new study published in Environmental Science & Technology.

Most previous research focused on one plastic at a time and their effect on soil function and nutrient cycling, but microplastics do not tend to occur in isolation.

in the present study, the researchers went for the combined effect of various types of plastics on soil and key functions, such as the nitrogen cycle.

To quantify the problem, the team ran a microcosm experiment in the lab, using soil samples mixed with six different types of plastic, including polyethylene terephthalate (PET) and polyvinyl chloride (PVC). They created four distinct groups with varying levels of plastic, from zero plastics (the control group) to five different types of plastic. After 40 days of incubation, they collected the soil and ran several tests. These included measuring soil properties, such as acidity and key enzyme activities, as well as DNA sequencing to identify bacteria and their associated functional genes.

The team's analysis revealed that increasing microplastic diversity leads to significant shifts in soil health. For example, the plastic mixture considerably raised soil pH (making the soil more alkaline) and increased soil carbon content.

However, one of the most important findings was that microplastic diversity boosted the activity of bacterial genes responsible for denitrification. This is the process by which bacteria convert plant nutrient material into nitrogen gas, which is then released into the atmosphere. It not only makes the soil less fertile, but also releases nitrous oxide, a greenhouse gas that is around 300 times more potent in warming the planet than carbon dioxide. The primary cause of this accelerated nitrogen loss was a family of bacteria known as Rhodocyclaceae.

Tian-Gui Cai et al, Microplastic Diversity as a Potential Driver of Soil Denitrification Shifts, Environmental Science & Technology (2025). DOI: 10.1021/acs.est.5c04981

Comment by Dr. Krishna Kumari Challa yesterday

Microlightning causes eerie lights of lore
Spontaneous flashes of ‘microlightning’ between bubbles of gas could explain will-o’-the-wisps — flickering lights that can appear on marshlands. Researchers blew tiny bubbles of methane and air into water, where smaller bubbles took on a negative charge and larger ones, a positive charge. As the charges equalized, they produced a small zap of electricity and a flash of light. This could explain why the ghostly-looking lights appear over methane-rich bogs.

https://www.pnas.org/doi/10.1073/pnas.2521255122

Comment by Dr. Krishna Kumari Challa yesterday

Dads influence embryo growth via molecular signatures, research reveals

Over the past few decades, growing evidence has challenged the belief that inheritance is governed solely by DNA sequences. Scientists now recognize the crucial role of epigenetic inheritance—the transmission of biological traits via chemical modifications to DNA and its associated proteins. These modifications do not alter the genetic code itself but influence how genes are switched on or off, often in response to environmental factors such as stress, diet, or drug exposure.

While the concept of maternal epigenetic inheritance is relatively intuitive—given the direct biological connection between mother and embryo during gestation—recent research shows that fathers, too, can transmit environmentally induced epigenetic changes to their offspring. However, the prevalence of epigenetic inheritance—and the mechanisms behind it—remains unclear.

In a recent study, researchers demonstrated that disrupting the gut microbiome of male mice increases disease risk in their future offspring. On the other hand, some have focused on mechanisms that regulate embryonic development in response to changes in paternal diet.
A collaborative study between the  groups, now published in The EMBO Journal, examined how specific paternal environments affect early embryonic development in a systematic manner and under tightly controlled genetic and environmental conditions in mice.

To induce environmental perturbations, prospective fathers were exposed to either non-absorbable antibiotics (disrupting the gut microbiota) or to a low-protein, high-sugar diet. To minimize experimental variability, the analyses were performed on embryos resulting from in vitro fertilization (IVF). Embryos were collected approximately four days after fertilization (blastocyst stage) and individually analyzed to measure differences in gene expression compared to controls (blastocysts that resulted from fathers without any treatment).
The results were striking. Both environmental perturbations led to significant changes in embryonic gene expression. Disruption of the paternal gut microbiota reduced the expression of key genes involved in extra-embryonic tissue development, while changes in the diet were linked with a modest developmental delay.

To further investigate the influence of the genetic background, scientists repeated the experiments using a different mouse strain. The outcome differed, suggesting the importance of the genetic component in shaping how environmental exposures affect offspring.

Additionally, embryos derived from older fathers showed a stronger effect on gene expression, especially on genes involved in immune-related processes, indicating that paternal age is another important factor involved in epigenetic inheritance.

Mathilde Dura et al, Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds, The EMBO Journal (2025). DOI: 10.1038/s44318-025-00556-4

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