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Comment by Dr. Krishna Kumari Challa 15 hours ago

Computers that run on human brain cells
At a company on the shores of Lake Geneva, clumps of living brain cells are waiting for your call. These blobs, about the size of a grain of sand, are available to research teams studying how brains work or exploring the possibility of making computers with brain-cell processors. These neural cells can receive electrical signals and respond to them — much as computers do. For some scientists, the dream is to build supercomputers that share the astonishing power efficiency of the human brain. What they’re not working on, they emphasize, is ‘brains in jars’: the blobs are not sentient or conscious (yet).

https://www.nature.com/articles/d41586-025-03633-0?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa 15 hours ago

Canada ( and entire Americas region) loses measles elimination status
Canada no longer holds measles elimination status after experiencing a cross-country outbreak that has persisted for more than 12 months. By default, this means that the entire Americas region has also lost its status. Infections took hold in undervaccinated Mennonite communities where the COVID-19 pandemic eroded already-shaky trust in the healthcare system — a shared source of recent measles outbreaks in the United States. The number of new cases is going down, but the loss is “a giant wake-up call that we have gaps in our public health infrastructure”, says physician-scientist Isaac Bogoch.

https://www.cbc.ca/news/health/livestory/canada-measles-elimination...

Comment by Dr. Krishna Kumari Challa 15 hours ago

Being multilingual es bueno para el cerebro

Want a younger brain? Learn another language

A vast study suggests that being multilingual can slow down cognitive ageing.

The ability to speak more than one language might slow brain ageing and protect against cognitive decline. In a study of more than 80,000 people, researchers found that people who are multilingual are half as likely to show signs of accelerated biological ageing than are those who just speak one language. The effect was also larger in people that spoke more than one additional language. The researchers hope that their findings will influence policy makers to encourage language learning in education.

I learnt five languages. Can my brain stay forever young?

https://www.nature.com/articles/s43587-025-01000-2.epdf?sharing_tok...

https://www.nature.com/articles/d41586-025-03677-2?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa 16 hours ago

Did You Know? The "Big Four" are not the only dangerous snakes of India: While the four species are responsible for the most bites, India is home to over 350 snake species, nearly 60 of which are considered clinically relevant to humans.

https://researchmatters.in/news/age-not-sex-or-location-determines-....

Comment by Dr. Krishna Kumari Challa 16 hours ago

Age, not sex or location, determines venom yield of India's 'Big Four' snakes, shows study

A new study by researchers from the Indian Institute of Science (IISc) has shown that the amount of venom produced by the big four snakes is overwhelmingly determined by the snake's life stage (age) rather than its sex or geographic location. The finding could have immediate implications for improving antivenom production and clinical treatment across the subcontinent.

To understand how much venom each snake delivers per bite, the researchers collected and quantified venom from the big four snakes across India's major bioclimatic zones. They collected venom samples from 338 wild-caught snakes during rescue operations coordinated with State Forest Departments and local snake rescuers across 10 states in India between 2021 and 2024. The venom was collected by experienced herpetologists using safe handling methods, encouraging the snake to bite onto a sterile parafilm stretched over a beaker. After extraction, all snakes were safely returned to their natural habitats. The collected crude venom was then freeze-dried (lyophilised) and its dry weight measured using a high-precision microbalance. This systematic, pan-Indian approach to sampling wild populations yielded a vast, diverse dataset.

The findings reveal substantial variation in venom output among the species, a pattern that largely correlates with the snake's overall body size. The two larger species, the Spectacled Cobra and the Russell's Viper, were the high-yield producers, meaning they delivered large quantities of venom with every bite. They averaged 136.10 mg and 106.60 mg of dry venom, respectively. In stark contrast, the smaller Common Krait (Bungarus caeruleus) and the Saw-scaled Viper (Echis carinatus) produced significantly less, with average yields of only 8.95 mg and 2.76 mg.

The most significant factor influencing this yield, however, was the snake's developmental stage. The study found statistically significant differences in venom yield across life stages for the cobra, Russell's viper, and saw-scaled viper. For example, adult Spectacled Cobras had a median venom yield of 125.00 mg, which is nearly three times the 47.60 mg median yield of subadults and almost twenty times the 6.50 mg median yield of juveniles. Similar trends were observed in Russell's Viper, with adults producing the highest median yield (95.69 mg) compared to juveniles (3.00 mg). This pattern strongly suggests that as a snake grows and matures, its capacity to produce and deliver venom increases dramatically.

Interestingly, the researchers found that sex-based differences were statistically insignificant across all four species.

Hiss and tell: What influences venom yields of India’s big four snakes?

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd....

Comment by Dr. Krishna Kumari Challa 16 hours ago

The team also examined whether the brain's capacity for long-term potentiation (LTP), a cellular basis of learning and memory, changes with time of day. This represents the brain's potential for metaplasticity (the brain's ability to adjust how easily its networks change). Remarkably, repetitive optical stimulation induced LTP-like enhancement at sunrise, but not at sunset.

This was unexpected, as it suggests that although sleep pressure and fatigue peak at sunrise, the brain's metaplastic potential is heightened at this time. These findings indicate that the brain's ability to reorganize itself follows a daily rhythm, with specific periods more favorable for learning and adaptation.

These results imply that our brains have temporal windows that favor adaptability.
Knowing when the brain is most receptive to changing could help optimize training, rehabilitation, and stimulation-based therapies.
In humans, who are mainly active during daylight hours, the capacity for learning and memory formation may peak during the twilight period approaching sunset. In other words, the best time to study or learn something new may be before bedtime.

The study reveals how daily rhythms fine-tune the balance between excitability and plasticity in the cortex. Because adenosine levels and sleep pressure follow circadian patterns, this mechanism may synchronize brain adaptability with behavioral cycles such as rest and activity. The research provides new insight into how the brain coordinates energy use, neural signaling, and learning capacity across the day.

Yuki Donen et al, Diurnal modulation of optogenetically evoked neural signals, Neuroscience Research (2025). DOI: 10.1016/j.neures.2025.104981

Part 2

Comment by Dr. Krishna Kumari Challa 16 hours ago

The flexible brain: How circuit excitability and plasticity shift across the day

Our brains do not react in a fixed, mechanical way like electronic circuits. Even if we see the same scene every day on our commute to work, what we feel—and whether it leaves a lasting impression—depends on our internal state at that moment. For example, your commute may be a blur if you're too tired to pay attention to your surroundings.

The 24-hour cycle that humans naturally follow is one of the factors that shapes the brain's internal environment. These internal physiological cycles arise from the interplay between the body's intrinsic circadian clock and the external light-dark cycle that synchronizes it. Yet how such daily fluctuations influence brain chemistry and affect neuronal excitability and plasticity has remained largely unknown.

Now, researchers  have directly observed time-of-day-dependent changes in neural signal responses in the brains of nocturnal rats. Their findings are published in Neuroscience Research.

Using optogenetics, the team activated neurons in the visual cortexes of rats and recorded the resulting electrical activity. This approach allowed precise quantification of neural responsiveness. They found that identical neural stimuli evoked different responses depending on the time of day. Neural activity was reduced at sunrise and enhanced at sunset. Since rats are nocturnal, sunrise represents the period after a night of activity when they are preparing to sleep.

To explore the underlying mechanism explaining why this was occurring, the researchers looked at adenosine, a neuromodulator that accumulates during wakefulness and makes us feel sleepy.

When the researchers blocked the action of adenosine, neural activity at sunrise became disinhibited and enhanced, showing that adenosine helps regulate cortical excitability across the day.

So neural excitability is not constant; it depends on the brain's internal state. 

The results show that even identical neurons can respond differently depending on the time of day, governed by molecules like adenosine that link metabolism, sleep, and neuronal signaling.

Part 1

Comment by Dr. Krishna Kumari Challa 16 hours ago

Pancreatic cancer forms 'synapses,' scientists discover

Pancreatic cancer cells form pseudosynapses that exploit the nervous system by taking up glutamate via NMDA receptors, triggering calcium influx and sustained signaling that promotes tumor growth and metastasis. Blocking these receptors in mice slowed tumor progression and reduced metastases, suggesting a potential therapeutic target. Similar mechanisms may exist in other tumor types.

Lei Ren et al, Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses, Cancer Cell (2025). DOI: 10.1016/j.ccell.2025.09.003

Comment by Dr. Krishna Kumari Challa 16 hours ago

Paradoxical suppression refers to the attempt to suppress a thought, feeling or behavior and it results in the opposite outcome.

Higher activation in the reward system regions occurred when participants' teams scored against rivals versus non-rivals, suggesting in-group bonding and social identity reinforcement.
The effect is strongest in highly fanatic participants, predicting momentary self-regulatory failure precisely when identity is threatened and accounting for the puzzling ability of otherwise rational individuals to suddenly "flip" at matches.
Clinically, the pattern implies a state-dependent vulnerability whereby a brief cooling-off or removal from triggers might permit the dACC/salience control system to recover.
The same neural signature—reward up, control down under rivalry—likely generalizes beyond sport to political and sectarian conflicts, say the researchers.
The neural results identify mechanisms which may inform communication, crowd management, and prevention strategies around high-stakes events in the reward amplification and control down-regulation under rivalry, they conclude.

Brain Mechanisms across the Spectrum of Engagement in Football Fans: A Functional Neuroimaging Study, Radiology (2025).

Part 2

Comment by Dr. Krishna Kumari Challa 16 hours ago

Brain activity goes to extremes in soccer fans, neuroimaging reveals

Studying brain patterns in soccer fans, researchers found that certain circuit regions of the brain were activated while viewing soccer matches involving their favorite team, triggering positive and negative emotions and behaviors, according to a new study published in Radiology. The researchers say these patterns could apply to other types of fanaticism as well, and that the circuits are forged early in life.

Soccer is a global phenomenon, and its followers exhibit a broad spectrum of behaviors, from spectatorship to intense emotional engagement, providing a useful model for studying social identity and emotional processing in competitive situations.

Rivalries run deep in the history of sports, and fans can be very protective of their "home" team and favorite players. These same fans run the gamut of emotions watching their team succeed or fail over the course of a game or match, cheering when they score or raging at a bad call. Soccer fans are known for their team loyalty and enthusiasm, particularly in Europe and South America.

Soccer fandom provides a high-ecological-validity model of fanaticism with quantifiable life consequences for health and collective behaviour.

For the study, researchers used functional MRI (fMRI)—a technique that measures brain activity by detecting changes in blood flow—to examine 60 healthy male soccer fans (20–45 years) of two historical rivals. Fanaticism was quantified with the Football Supporters Fanaticism Scale, a 13-item scale that measures the fanaticism of football fans, assessing two sub-dimensions: "Inclination to Violence" and "Sense of Belongingness."

Brain imaging data were acquired while participants watched 63 goal sequences from matches involving their favorite team, a rival or a neutral team.

A whole-brain analysis was conducted to compare neural responses when participants viewed their favorite team scoring against an archrival (significant victory) versus when the archrival scored against their team (significant defeat), with control conditions for non-rival goals.

The fMRI results showed that brain activity changed when the fan's team succeeded or failed.

Rivalry rapidly reconfigures the brain's valuation–control balance within seconds. With significant victory, the reward circuitry in the brain is amplified relative to non-rival wins, whereas in significant defeat the dorsal anterior cingulate cortex (dACC)—which plays an important role in cognitive control—shows paradoxical suppression of control signals.

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