Comment

Comment by Dr. Krishna Kumari Challa on December 21, 2022 at 11:40am

Developing antibiotics that target multiple-drug-resistant bacteria

Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.

Antibiotics are vital drugs in the treatment of a number of bacterial diseases. However, due to continuing overuse and misuse, the number of bacteria strains that are resistant to multiple antibiotics is increasing, affecting millions of people worldwide. The development of new antibacterial compounds that target multiple drug resistant bacteria is also an active field of research so that this growing issue can be controlled.

Scientists have been working on the development of new antibacterials. Their most recent research, published in the journal Nature Communications, details the development of a highly effective antibacterial compound that is effective against the most common multidrug-resistant bacteria.

 worked on a class of antibacterial compounds called sphaerimicins. These compounds block the function of a protein in the bacteria called MraY. MraY is essential for the replication of bacteria and plays a role in the synthesis of the bacterial cell wall; it is also not a target of currently available commercial antibiotics.

The team analyzed structures of sphaerimicin A by molecular modeling assisted by calculation, and designed and synthesized two analogs of sphaerimicin, SPM1 and SPM2. These analogs were found to be effective against Gram positive bacteria.

They then determined the structure of SPM1 bound to MraY. By studying this structure and comparing it to that of related antibacterial agents, they determined how to further simplify the molecules. They were successful in developing a simpler analog, SPM3, whose activity was similar to SPM1.

In addition to their effectiveness against MRSA and VRE, the SPMs were also effective against Mycobacterium tuberculosis, the bacteria that causes tuberculosis—and which has multidrug-resistant strains.

Satoshi Ichikawa et al, Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY, Nature Communications (2022). DOI: 10.1038/s41467-022-35227-z

**

Comment by Dr. Krishna Kumari Challa on December 20, 2022 at 8:17am

Study uncovers existing limitations in the detection of entanglement

Quantum entanglement is a process through which two particles become entangled and remain connected over time, even when separated by large distances. Detecting this phenomenon is of crucial importance for both the development of quantum technology and the study of quantum many-body physics.

Researchers  have recently carried out a study exploring the possible reasons why the reliable and efficient detection of entanglement in complex and "noisy" systems has often proved to be very challenging. Their findings, published in Physical Review Letters, hint at the existence of a trade-off between the effectiveness and efficiency of entanglement detection methods.

This new work showed that to observe entanglement on a large-scale, researchers must be able to control all interactions in a system with high precision and know almost all information about them. When there is a lot of uncertainty about the system, therefore, the probability of detecting its entanglement is very small, even if one is almost certain of its occurrence.

This proved that no entanglement detection protocols are both efficient and effective. This may help the design of entanglement detection protocols in the future.

Pengyu Liu et al, Fundamental Limitation on the Detectability of Entanglement, Physical Review Letters (2022). DOI: 10.1103/PhysRevLett.129.230503

Karol Życzkowski et al, Volume of the set of separable states, Physical Review A (2002). DOI: 10.1103/PhysRevA.58.883

Leonid Gurvits et al, Largest separable balls around the maximally mixed bipartite quantum state, Physical Review A (2002). DOI: 10.1103/PhysRevA.66.062311

Stanislaw J. Szarek, Volume of separable states is super-doubly-exponentially small in the number of qubits, Physical Review A (2005). DOI: 10.1103/PhysRevA.72.032304

Xi-Lin Wang et al, 18-Qubit Entanglement with Six Photons' Three Degrees of Freedom, Physical Review Letters (2018). DOI: 10.1103/PhysRevLett.120.260502

Comment by Dr. Krishna Kumari Challa on December 19, 2022 at 2:12pm

Gold-based passive heating for eyewear

Comment by Dr. Krishna Kumari Challa on December 17, 2022 at 11:48am

From COVID-19 to the common cold: scientists identify broadly effective, infection-halting compound

Researchers have identified a compound that shows early promise at halting infections from a range of coronaviruses, including all variants of SARS-CoV-2 and the common cold. The findings, published this week in Molecular Biomedicine, reveal a potential path toward antiviral treatments that could be used against many different pathogens.

Beyond COVID-19, there are many different types of coronaviruses that can cause serious and sometimes fatal disease, and even more are likely to emerge in the future. 

The researchers credit the compound’s broad effectiveness to the unique way it works. Rather than targeting the virus itself, the compound targets a human cellular process that coronaviruses use to replicate.

Since viruses can’t reproduce on their own, they rely on protein-synthesis pathways in host cells to create copies of themselves. In the case of coronaviruses, they use a human enzyme called GSK3 beta that exists in all human cells.

Scientists found that coronaviruses hijack this human enzyme and use it to edit the protein that packs its genetic material. This compound blocks GSK3 beta, which in turn, stops the virus from reproducing and maturing its proteins.

The compound is part of a broader family of experimental drugs known as GSK3 inhibitors. Since the late 1990s, scientists across academia and industry have been studying GSK3 inhibitors for their potential as treatments for a number of diseases, including diabetes, Alzheimer’s and cancer.

By targeting this cellular pathway, rather than the virus itself, scientists see broad activity against multiple pathogens. We’re also acting on a pathway that is so far immune to changes between variants and different coronaviruses.

https://link.springer.com/article/10.1186/s43556-022-00111-1

Comment by Dr. Krishna Kumari Challa on December 17, 2022 at 11:38am

This pro-inflammatory impact was highly unexpected. Our work shows that the protein binds to an interleukin receptor in the skin that is known to play a key role in driving psoriasis. And, to add further intrigue to the story, this brings the total number of immune alarm molecules that signal via this particular interleukin receptor to four.

"Why there are so many interleukins that bind to the same receptor is a mystery, but if we were to speculate it may be because this receptor serves a very important sentinel function in our skin, and that one alarm protein may simply not be enough to respond to the many different infectious agents that our skin encounters. Our skin is the major barrier between our bodies and the outside world that microbes must breach if they are to gain entry to our bodies and, in many respects, represents the first line of defense in our immune systems."

As such, Interleukin-37 and other immune alarm  proteins may have evolved to become distinct variations on the same theme that enable our bodies to detect different types of infection by becoming activated by enzymes that are distinct to each infectious agent.

 Graeme P. Sullivan et al, Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement, Science Immunology (2022). DOI: 10.1126/sciimmunol.ade5728. www.science.org/doi/10.1126/sciimmunol.ade5728

Part 2

Comment by Dr. Krishna Kumari Challa on December 17, 2022 at 11:37am

Immune surprise: Recently evolved alarm molecule drives inflammation

Scientists  have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the opposite.

Their work has numerous potential impacts, especially in the context of understanding and responding to autoimmune disorders and inflammation.

While our immune system serves a very important function protecting us from infection and injury, when immune responses become too aggressive this can lead to damaging inflammation, which occurs in conditions such as rheumatoid arthritis and psoriasis. Inflammation is triggered when our bodies produce "alarm proteins" (interleukins), which ramp up our defenses against infection and injury by switching on different components of our immune system.

Understanding how and when such alarm proteins are produced and how they activate our immune system has led to major breakthroughs in the treatment of many immune conditions.

Now, scientists  have found that Interleukin-37 has an unexpected function as an immune-activating molecule, as previous studies suggested that this interleukin instead served as an "off switch" for the immune system.

Prior to the new study, Interleukin-37 was thought to have immune-suppressive functions but how exactly it switched off inflammation was hotly debated. However, the scientists now report that, when activated in the correct way, Interleukin-37 displays potent pro-inflammatory activity.

Part 1

Comment by Dr. Krishna Kumari Challa on December 17, 2022 at 10:52am

Study finds higher levels of common diet-associated microbe elevates heart failure risk

New research  expands the link between what we eat and how the gut microbiome impacts our susceptibility to develop different diseases—in this case, how a specific gut microbe-generated byproduct is linked to heart failure risk.

Elevated levels of phenylacetylglutamine (PAG)—a byproduct created when microbes in the gut breakdown dietary protein—can be directly linked to both increased heart failure risk and severity, according to findings published in Circulation: Heart Failure.

The new findings improve researchers' understanding of how the gut microbiome, through PAG levels, are linked to cardiac disease risks, and suggest potential approaches to modify PAG-associated risks through interventions such as diet and beta blocker use.

Elevated PAG levels also were shown to correspond with types of heart failure. For example, elevated blood PAG was observed in subjects with heart failure with preserved ejection fraction, a condition where the heart muscle doesn't relax enough between beats and becomes too stiff, making it less able to fill and consequently pump blood.

Kymberleigh A. Romano et al, Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure, Circulation: Heart Failure (2022). DOI: 10.1161/CIRCHEARTFAILURE.122.009972

Ina Nemet et al, A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors, Cell (2020). DOI: 10.1016/j.cell.2020.02.016

Comment by Dr. Krishna Kumari Challa on December 16, 2022 at 11:19am

Physics-Based Planning for Generalizable Assembly by Disassembly

Comment by Dr. Krishna Kumari Challa on December 15, 2022 at 12:09pm

Discovery could explain why women are more likely to get Alzheimer's

Scientists  have found a clue to the molecular cause of Alzheimer's—a clue that may also explain why women are at greater risk for the disease.

In the study, reported on December 14, 2022, in Science Advances, the researchers found that a particularly harmful, chemically modified form of an inflammatory immune protein called complement C3 was present at much higher levels in the brains of women who had died with the disease, compared to men who had died with the disease. They also showed that estrogen—which drops in production during menopause—normally protects against the creation of this form of complement C3.

These new findings suggest that chemical modification of a component of the complement system helps drive Alzheimer's, and may explain, at least in part, why the disease predominantly affects women.

Hongmei Yang et al, Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3, Science Advances (2022). DOI: 10.1126/sciadv.ade0764. www.science.org/doi/10.1126/sciadv.ade0764

Comment by Dr. Krishna Kumari Challa on December 15, 2022 at 11:57am

Pollination loss removes healthy foods from global diets, increases chronic diseases causing excess deaths

Inadequate pollination has led to a 3-5% loss of fruit, vegetable, and nut production and an estimated 427,000 excess deaths annually from lost healthy food consumption and associated diseases, including heart disease, stroke, diabetes, and certain cancers, according to research. It is the first study to quantify the human health toll of insufficient wild (animal) pollinators on human health.

A critical missing piece in the biodiversity discussion has been a lack of direct linkages to human health. This research establishes that loss of pollinators is already impacting health on a scale with other global health risk factors, such as prostate cancer or substance use disorders.

Increasing human pressure on natural systems is causing alarming losses in biodiversity, the topic of the COP 15 UN Biodiversity Conference currently taking place in Montreal. This includes 1-2% annual declines of insect populations, leading some to warn of an impending "insect apocalypse" in the coming decades. Key among insect species are pollinators, which increase yields of three-fourths of crop varieties and are critical to growing healthy foods like fruits, vegetables, and nuts. Changes in land-use, use of harmful pesticides, and advancing climate change threaten wild pollinators, imperiling human supply of healthy foods. The researchers used a model framework, which included empirical evidence from a network of hundreds of experimental farms across Asia, Africa, Europe and Latin America, that looked at "pollinator yield gaps" for the most important pollinator-dependent crops, to show how much crop loss was due to insufficient pollination. They then used a global risk-disease model to estimate the health impacts the changes in pollination could have on dietary risks and mortality by country. Additionally, they calculated the loss of economic value from lost pollination in three case study countries. The results showed that lost food production was concentrated in lower-income countries but that the health burden was greater in middle- and higher-income countries, where rates of non-communicable diseases are higher. The geographic distribution was somewhat unusual in that generally the health effects from global environmental change are centered among the poorest populations in regions such as South Asia and Sub-Saharan Africa. Here, middle-income countries with large populations—China, India, Indonesia, and Russia—suffered the greatest burden. The analysis also showed that lower-income countries lost significant agricultural income due to insufficient pollination and lower yields, potentially 10-30% of total agricultural value.

Strategies to protect wild pollinators are not just an environmental issue, but a health and economic one as well. This study shows that doing too little to help pollinators does not just harm nature, but human health as well.

Pollinator deficits, food consumption, and consequences for human health: a modeling study, Environmental Health Perspectives (2022). DOI: 10.1289/EHP10947

• ‹ Previous
• 1
• …
• 434
• 435
• 436
• 437
• 438
• …
• 1074
• Next ›
• Page